Catalyst hub redevelopment positions St. Louis as a rising leader in bioscience innovation

What once stood as the headquarters of a nonprofit serving people with disabilities is being reborn into a cornerstone of St. Louis’ life-sciences economy. Washington University in St. Louis and its development affiliates have broken ground on Catalyst: Powered by WashU, a $100 million transformation of the former Goodwill Industries complex into a dynamic bioscience innovation hub in the heart of the Cortex Innovation District.

The seven-story midcentury building at 4140 Forest Park Blvd., long vacant since Goodwill’s departure, is undergoing extensive renovation and expansion. The 120,000 SF historic structure will be restored and integrated with a new 50,000 SF, four-story addition, creating roughly 163,000 SF of modern lab, office, and collaboration space tailored to mid- and late-stage bioscience startups.

Washington University’s affiliate BOBB LLC is leading the redevelopment with HOK as the project’s architect and Tarlton as construction manager. The redevelopment aims not only to preserve architectural character — the building is on the National Register of Historic Places — but also to enhance it with contemporary amenities, including a ground-floor lobby with a coffee bar and shared meeting areas, and multiple elevators to improve access throughout the facility.

Officials describe Catalyst as graduation space — high-quality infrastructure that enables bioscience companies to scale operations beyond the early incubator phase. Cortex, the 200-acre innovation community co-founded by WashU and anchored in Midtown, has long attracted startups and established players alike by offering access to talent, capital, and facilities. Still, demand for wet labs and specialized space has outpaced supply, making Catalyst’s arrival timely for the region’s ecosystem.

C2N Diagnostics, a local success story with deep WashU roots, is the anchor tenant and first occupant. The company, known for developing advanced blood tests for Alzheimer’s disease and other neurodegenerative conditions, will lease more than 82,000 SF for its headquarters and CLIA-certified laboratory, occupying the first three floors. C2N’s expansion is expected to elevate both its global impact and local job creation.

Doug Frantz, WashU’s vice chancellor for innovation and commercialization, noted that the redevelopment represents far more than a simple property upgrade. He emphasized that Catalyst is designed to unlock new potential by reducing barriers for startups moving toward commercialization.

Cortex leaders believe the new hub will play a central role in attracting and retaining top scientific talent, helping ensure that major breakthroughs developed in St. Louis continue to grow there. Cortex CEO Sam Fiorello has described the project as a strong demonstration of regional collaboration that reinforces the city’s standing as a leading destination for biotech and life sciences.

Construction continues through 2026, with C2N’s move planned for late that year and additional lab and office spaces available for lease. As Catalyst rises from its historic roots, it embodies both St. Louis’ industrial legacy and its aspirations as a national innovation leader. 

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Header image: A rendering of a common area within the four-story, 163,000 SF Catalyst redevelopment in the Cortex Innovation District of WashU. Image | HOK

New office HQ with a view for Arcturis

Renovations are underway on new office headquarters for Arcturis, a St. Louis-based national design firm, who plans to move to the 13th floor of the former Peabody Plaza building, which now serves as a focal point of the new Gateway Plaza at 701 Market St. in downtown St. Louis.

Arcturis partnered with Tarlton Corp. to serve as construction manager of the 11,500-SF, build-out project - adding to the award-winning portfolio of the two, women-owned businesses.

The dynamic duo previously collaborated on the build-out of the new Spire corporate headquarters which earned LEED Gold for Commercial Interiors certification from the U.S. Green Building Council and was recognized with an Edwin F. Guth Award for interior lighting design from the Illuminating Engineering Society.

Slated for completion by the end of this year, the renovations and tenant build-out include the demolition of existing office space; installation of new partitions; high-end, industrial-look finishes and MEPFP design-build enhancements.

An impressive glass-wall storefront, fabricated and installed by Missouri Valley Glass, welcomes employees and visitors into the office suite. The storefront features one-half-inch-thick clear tempered glass sections situated within a span that is 9 feet tall and 22 feet long. The entry doors are flanked by two wide sections on each side, with sleek, brushed stainless hardware and trim completing the modern design.

In addition, the office space incorporates a wellness area featuring a lounge and cafeteria, as well as a “light laboratory” that Arcturis design teams will use for fixture testing and to simulate different light conditions in project designs for clients.

The Tarlton project team includes Joe Scarfino, project director; Diane Grimsley, senior project manager; Beth Barton, superintendent; and Joe Carr, cost engineer.

AGCMO announces Keystone Awards, SCOTY winners

The Associated General Contractors of Missouri (AGCMO) has named Spirtas Wrecking Corporation as its Specialty Contractor of the Year in the Environmental Remediation and Demolition services category.

Spirtas received first place in this discipline by the general contractor members of AGCMO, who were asked to consider their overall experience with Spirtas, including timeliness in regard to completion of projects and ability to stay within budget.

“The need for environmentally responsible remediation and demolition has never been greater, and this industry recognition underscores our commitment to leading the way in this sector,” said Matt Sheehan, president and CEO of Spirtas.

Over the past year, Spirtas has completed 75 environmental remediation and demolition projects in support of Forsyth Pointe, Covenant House Wellness Center, St Mary’s Hospital Convent and the Muskingham River Power Plant in Ohio.

The annual awards program highlights the creativity and talents of dozens of contractors in Missouri’s construction industry. Along with Spirtas, the following contractors received Specialty Contractor of the Year (SCOTY) Awards. (Keystone Awards follow SCOTY Awards):

• ROSCH (ancillary services);

• Vee-Jay Cement Contracting Co. Inc. (concrete / paving);

• Budrovich Excavating & Contracting (earthwork and utilities);

• Guarantee Electrical Co. (electrical);

• TJ Wies Contracting Inc. (interior and exterior finishes, openings and fixtures);

• Charles E. Jarrell Contracting Co. Inc. (HVAC / piping);

• Grant Masonry Contracting Co. Inc. (masonry);

• Boyer Fire Protection (plumbing and fire protection);

• BAM Contracting LLC (structural and finish carpentry);

• ACME Erectors Inc. (structural and finish metals);

• Geissler Roofing Co. Inc. (thermal and moisture protection).

The following contractors received AGMO’s 2020 Construction Keystone Awards.

• Murphy Co. for the Enterprise Center Quad D AHU Replacement;

• PARIC for the Union Station Wheel and Train Park;

• Tarlton Corp. for The Muny Stage and Production Improvements;

• McCarthy Building Companies for the East End Transformation of the Washington University in St. Louis Danforth Campus;

• Massman Construction Co. for the Grand River Bridge Emergency Replacement in Brunswick, Missouri;

• Acme Erectors Inc. for The Vertical Garden in the Steward Family Plaza;

• TJ Wies Contracting Inc. for the State Historical Society in Columbia;

• Murphy Co. for Centene Community Ice Center;

• Murphy Co. for Centene Urban Campus Clayton High Rise;

• icon Mechanical Construction & Engineering LLC for the Pfizer BioPlace New Research & Development Facility;

• ACME Constructors Inc. for Agra Form’s 4-Phased Plant Expansion

• Guarantee Electrical Co. was awarded Keystone Project of the Year in the special coronavirus pandemic response category for construction of the U.S. Army Corps of Engineer’s COVID-19 Alternate Care Facility.

The Associated General Contractors of Missouri is the united voice of the construction industry, representing over 500 commercial, industrial, heavy and highway contractors, industry partners and related firms in 110 counties in Missouri. Last month, AGCMO was named large Chapter of the Year by AGC of America. AGCMO operates offices in St. Louis, Jefferson City and Springfield.

Tarlton's fast-track hospital back-up facility wins award

Tarlton Corp., a St. Louis-based general contracting and construction management firm, recently received a 2020 Award of Merit in the 'Best Projects' category from ENR Midwest for completion of a COVID-19 alternate care facility in Florissant, Mo. for the U.S. Army Corps of Engineers (USACE).

Tarlton Corp. assisted USACE and coordinated with multiple government and health agencies to transform the Quality Inn at 55 Dunn Road into an alternate healthcare facility for patients referred by St. Louis-area hospitals for non-acute COVID-19 treatment.

The conversion was completed April 11, 2020 – less than 80 hours after construction work began. After opening several days later, the facility was staffed by members of the U.S. National Guard.

Tarlton led the design-build team in this unprecedented fast-track project, building in two shifts around the clock with more than 100 employees from four firms. Design-build partners were Ross & Baruzzini, Rock Hill Mechanical Corp. and Guarantee Electrical Co. Subcontractors included C&R Mechanical’s Plumbing Division, Collins & Hermann, Dynamic Air Solutions, Flooring Systems Inc., Jos. Ward Painting Co., Midwest Elevator, Stanley Steemer, Tech Electronics, Waterhout Construction and Woodard Cleaning and Restoration.

“I’m proud of the quick and thorough response our team put together and executed on this project,” said Tracy Hart, president of Tarlton. “We feel honored to be trusted by the U.S. Army Corps of Engineers for this mission-critical project for our community.”

The project yielded more than 100 patient rooms on the four floors of the 130-room hotel. Scope included stripping down and deep-cleaning individual rooms and placing extra beds and furniture in storage; changing door hardware for rooms and bathrooms to disable locking mechanisms; cleaning carpet throughout; removing and replacing carpet in specific areas; repainting certain walls and ceilings; building a nurse station and storage area on each floor; and converting the phone system into a nurse call system.

Tarlton’s award is one of only two projects selected from St. Louis, with 32 Best Projects selected from a slate of 112 entries received this year by ENR Midwest, which covers an 11-state region. The 2020 award-winning projects and firms will be featured in the November edition of ENR Midwest, with a virtual awards presentation scheduled for Dec. 3, 2020.