Mercy Hospital St. Louis has officially begun construction on its new $650 million hospital campus in Wentzville, marking Missouri's first ground-up acute care hospital in nearly a decade.

Situated on a 60-acre site at the intersection of Interstates 64 and 70, the 425,000-square-foot facility is designed to meet the needs of the region’s fast-growing tri-county area: St. Charles, Lincoln, and Warren counties.

The five-story hospital will include 75 inpatient beds, a 28-bay emergency department with two trauma bays and 18 observation beds, and specialized services for cardiovascular, cancer, and orthopedic care.

Outpatient imaging, diagnostics, and treatment services are also planned. Mercy has reserved adjacent land for future growth and medical campus expansion.

McCarthy Building Companies is leading construction, with CannonDesign providing architecture and planning. The team is committed to using 100% union labor from within the region.

The project is expected to be complete by 2029 and will create more than 1,000 healthcare jobs. Local leaders have praised the development for its economic and social impact.